Class NEET 2026 ALL Q #1984
COMPETENCY BASED
APPLY
4 Marks 2026 NTA-RE-NEET-2026 MCQ SINGLE
A protein undergoes reversible thermal denaturation from its initial state N to denatured state D according to $N \rightleftharpoons D$. At $60^{\circ}C$, the concentrations of both N and D are equal at equilibrium, and the standard enthalpy change of denaturation is $666~kJ~mol^{-1}$. The standard entropy change ($\Delta S^{\circ}$ in $kJ~K^{-1}~mol^{-1}$) of the protein upon denaturation at $60^{\circ}C$ is closest to
(A) 11.1
(B) 2
(C) 2000
(D) 333
Correct Answer: B

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Detailed Solution

Step 1: Identify the equilibrium condition

At equilibrium, the concentrations of N and D are equal, meaning $[N] = [D]$. The equilibrium constant $K_{eq}$ is defined as: $$K_{eq} = \frac{[D]}{[N]} = 1$$

Step 2: Relate equilibrium constant to Gibbs free energy

The standard Gibbs free energy change $\Delta G^{\circ}$ is related to $K_{eq}$ by the equation: $$\Delta G^{\circ} = -RT \ln(K_{eq})$$ Since $K_{eq} = 1$, $\ln(1) = 0$, therefore $\Delta G^{\circ} = 0$.

Step 3: Use the thermodynamic relation for Gibbs free energy

We know that $\Delta G^{\circ} = \Delta H^{\circ} - T\Delta S^{\circ}$. Given $\Delta G^{\circ} = 0$, we have: $$\Delta H^{\circ} = T\Delta S^{\circ}$$

Step 4: Calculate the entropy change

Convert the temperature to Kelvin: $T = 60 + 273.15 = 333.15 K$. Given $\Delta H^{\circ} = 666 kJ mol^{-1}$, we solve for $\Delta S^{\circ}$: $$\Delta S^{\circ} = \frac{\Delta H^{\circ}}{T} = \frac{666}{333.15} \approx 2 kJ K^{-1} mol^{-1}$$

Final Answer: 2

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Pedagogical Audit
Bloom's Analysis: This is an APPLY question because the student must integrate concepts from chemical equilibrium and thermodynamics to solve for a specific physical parameter.
Knowledge Dimension: PROCEDURAL
Justification: The student must follow a specific sequence of thermodynamic steps (Equilibrium -> Gibbs Free Energy -> Entropy calculation) to reach the result.
Syllabus Audit: In the context of NEET, this is classified as COMPETENCY. This question tests the ability to apply physical chemistry principles to biological systems (protein denaturation), which is a core requirement for modern NEET chemistry sections.
||KEY:B